--- title: "Mast Cell Therapeutics: A New Frontier in Dermatology Innovation & Investment. Interview with Dr. Brian Kim" description: Dr. Kim is a world-renowned immunology and neuroimmunology scientist, entrepreneur, and dermatologist. He discusses groundbreaking developments in mast cell therapeutics. image: https://blog.advancing-derm.org/hubfs/Mast%20Cell%20Therapeutics%20with%20Dr.%20Brian%20Kim-%20Blog%20Thumbnail.png --- [![AID-logo](https://blog.advancing-derm.org/hubfs/AID-logo.png "AID-logo")](https://www.advancing-derm.org) - [About](https://www.advancing-derm.org/about/) - [About](https://www.advancing-derm.org/about/) - [Vision / Mission](https://www.advancing-derm.org/about/) - [Our Strategic Partners](https://www.advancing-derm.org/about/partners/) - [People](https://www.advancing-derm.org/about/members/) - [Executive Committee & Board of Trustees](https://advancing-derm.org/about/members/executive-committee-board-of-trustees/) - [Conference and Program Leadership](https://advancing-derm.org/about/members/conference-and-program-leadership/) - [Platform](https://www.advancing-derm.org/platform/) - [Platform](https://www.advancing-derm.org/platform/) - [Leadership Councils](https://advancing-derm.org/platform/programs/leadership-councils/) - [Think Tank](https://www.advancing-derm.org/platform/dermatology-innovation-leadership-think-tank/) - [Programs](https://www.advancing-derm.org/platform/programs/) - [Conferences](https://www.advancing-derm.org/platform/conferences/) - [Hacking Dermatology](https://www.advancing-derm.org/hacking-dermatology/) - [AID Accelerator](https://www.advancing-derm.org/platform/programs/aid-accelerator/) - [Previous Programs](https://advancing-derm.org/about/success-stories/) - [Virtual Magic Wand](https://www.advancing-derm.org/platform/aid-scholars/virtual-magic-wand-program/) - [Scholars Class 2019](https://www.advancing-derm.org/scholars-class-2019/) - [Scholars Class 2018](https://www.advancing-derm.org/scholars-class-2018/) - [Scholars Class 2017](https://www.advancing-derm.org/scholars-class-2017/) - [Media](https://blog.advancing-derm.org) - Events - [Contact](https://www.advancing-derm.org/contact/) [Twitter](https://twitter.com/AdvancingDerm)  |    [LinkedIn](https://www.linkedin.com/company/advancing-innovation-in-dermatology-inc-/) [![](https://blog.advancing-derm.org/hubfs/AID-logo.png)](https://www.advancing-derm.org) - [MEDIA](https://blog.advancing-derm.org) - [EVENTS](https://www.advancing-derm.org/events) - [CONTACT](https://www.advancing-derm.org/contact) Menu - [About](https://www.advancing-derm.org/about) - [About](https://www.advancing-derm.org/about) - [Vision / Mission](https://www.advancing-derm.org/about) - [Our Strategic Partners](https://www.advancing-derm.org/about/partners) - [Success Stories](https://advancing-derm.org/about/success-stories/) - [PEOPLE](https://www.advancing-derm.org/about/members) - [Executive Committee & Board of Trustees](https://www.advancing-derm.org/about/members/executive-committee-board-of-trustees) - [Conference & Program Leadership](https://www.advancing-derm.org/about/members/conference-and-program-leadership) - [Platform](https://www.advancing-derm.org/platform) - [Programs](https://www.advancing-derm.org/platform/programs) - [Leadership Councils](https://www.advancing-derm.org/platform/programs/leadership-councils/) - [Previous Programs](https://advancing-derm.org/about/success-stories/) - [Conferences](https://www.advancing-derm.org/platform/conferences/) - [Dermatology Innovation Forum 2026](https://advancing-derm.org/platform/conferences/dermatology-innovation-forum-2026//) - [Dermatology Summit](https://advancing-derm.org/dermatology-summit/) - [Media](https://blog.advancing-derm.org) - [Events](https://www.advancing-derm.org/events) - [Contact](https://www.advancing-derm.org/contact) # Mast Cell Therapeutics: A New Frontier in Dermatology Innovation & Investment. Interview with Dr. Brian Kim ### Now Viewing Articles [View Events](https://pages.advancing-derm.org/resources?hs_preview=lxMkcykJ-77280682771) Advancing Innovation in Dermatology is pleased to make available our collection of scholar articles, industry news, and interviews with the professionals accelerating innovation in skin health and patient care. This content is yet another way beyond our in-person and virtual events to strengthen the community of innovators we aim to build and maintain. Oct 31, 2024 By: Advancing Innovation in Dermatology **Mast Cell Therapeutics: A  New Frontier in Dermatology Innovation and Investment** **An Interview with Dr. Brian Kim** *William Ju, MD, FAAD, president of* [*Advancing Innovation in Dermatology, Inc.*](https://www.linkedin.com/company/advancing-innovation-in-dermatology-inc-/)*, recently interviewed Brian S. Kim, MD, MTR, FAAD, the Sol & Clara Kest Professor of Dermatology & Vice Chair of Research, Department of Dermatology,* [*Icahn School of Medicine at Mount Sinai*](https://icahn.mssm.edu/about/departments-offices/dermatology)*, and Lead of the* [*Allen Discovery Center for Neuroimmune Interactions*](https://adcneuroimmune.org/)*.* *Dr. Kim is a world-renowned immunology and neuroimmunology scientist, entrepreneur, and dermatologist. Their discussion shed light on the groundbreaking developments in mast cell therapeutics, a field poised to potentially transform the landscape of dermatology and adjacent therapeutic areas.* You have organized and are chairing a session at the 2025  Dermatology Summit around the JP Morgan Healthcare Conference. It’s  titled "The New Paradigm of Mast Cell Therapies." Could you give us a high-level view of this paradigm and why it is significant to the health sciences product innovation community?  This new paradigm has come about because research is showing that mast cells play critical roles not only in allergic reactions but also in chronic inflammatory conditions, including dermatologic, respiratory,  and gastrointestinal diseases, and in pathological pain and itch that is neuroimmune-mediated.  In addition, research has identified new therapeutic targets for regulating mast cell activation and mediator release and reducing mast cell numbers. This forms the basis for a new frontier for breakthrough products. **What are the druggable targets?** We see numerous companies working in mast cell therapies that are in clinical and late-preclinical development. These include  Incyte, Evommune, Celldex Therapeutics, Jasper Therapeutics, Novartis, Allakos,  Granular Therapeutics, and Septerna. Among the targets are BTK, MRGPRX2, c-KIT, and Siglec-6. Regarding dermatological diseases,  innovative mast cell treatments are being developed for chronic spontaneous urticaria, chronic inducible urticaria, mast cell activation syndrome, atopic dermatitis, and others. **Could you give us a sneak preview of what will be presented in your session at the Dermatology Summit in San Francisco on January 12? ** Several of these forward-thinking companies I’ve mentioned have agreed to speak about the intriguing products in their development pipelines. We also plan to have a lively discussion after the presentations. I think the audience will come away with a unique, state-of-the-art understanding of the exciting and immense promise of mast cell drugs for addressing unmet needs that patients have in dermatology and in multiple other therapeutic areas. Join the conversation at our Annual Dermatology Summit on January 12, 2025 in San Francisco.  [Register and purchase tickets here!](https://www.accelevents.com/e/2025-Dermatology-Summit)   - [Tweet](https://twitter.com/share) ### AID In the News ### Posts by Tag - [News (32)](https://blog.advancing-derm.org/tag/news) - [Articles (31)](https://blog.advancing-derm.org/tag/articles) - [Interviews (10)](https://blog.advancing-derm.org/tag/interviews) - [Entrepreneurship (9)](https://blog.advancing-derm.org/tag/entrepreneurship) - [Events (4)](https://blog.advancing-derm.org/tag/events) - [Innovation Review (3)](https://blog.advancing-derm.org/tag/innovation-review) - [Press Releases (3)](https://blog.advancing-derm.org/tag/press-releases) - [AID Accelerator (2)](https://blog.advancing-derm.org/tag/aid-accelerator) - [Awards (2)](https://blog.advancing-derm.org/tag/awards) - [Dermatology (2)](https://blog.advancing-derm.org/tag/dermatology) - [Business (1)](https://blog.advancing-derm.org/tag/business) - [biotech (1)](https://blog.advancing-derm.org/tag/biotech) See all ![AID-logo-white](https://blog.advancing-derm.org/hs-fs/hubfs/AID-logo-white.png?width=300&height=183&name=AID-logo-white.png "AID-logo-white") ##### Quick Links - [Media](https://blog.advancing-derm.org/) - [Upcoming Events](https://www.advancing-derm.org/events) - [People](https://www.advancing-derm.org/about/members/) ##### Connect with us If you would like to contact Advancing Innovation in Dermatology Inc., please [contact us](https://www.advancing-derm.org/contact). ##### Signup for updates Advancing Innovation in Dermatology Inc. is a nonprofit, tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code. 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