--- title: "Innovation Spotlight: Diagnostics - Advancing Innovation in Dermatology" description: Recent innovations point to a clinical future where diagnostics are less invasive and information is tailored to individual patients. image: https://blog.advancing-derm.org/hubfs/Imported_Blog_Media/AID_Innovation_Diagnostics_800x400.png --- [![AID-logo](https://blog.advancing-derm.org/hubfs/AID-logo.png "AID-logo")](https://www.advancing-derm.org) - [About](https://www.advancing-derm.org/about/) - [About](https://www.advancing-derm.org/about/) - [Vision / Mission](https://www.advancing-derm.org/about/) - [Our Strategic Partners](https://www.advancing-derm.org/about/partners/) - [People](https://www.advancing-derm.org/about/members/) - [Executive Committee & Board of Trustees](https://advancing-derm.org/about/members/executive-committee-board-of-trustees/) - [Conference and Program Leadership](https://advancing-derm.org/about/members/conference-and-program-leadership/) - [Platform](https://www.advancing-derm.org/platform/) - [Platform](https://www.advancing-derm.org/platform/) - [Leadership Councils](https://advancing-derm.org/platform/programs/leadership-councils/) - [Think Tank](https://www.advancing-derm.org/platform/dermatology-innovation-leadership-think-tank/) - [Programs](https://www.advancing-derm.org/platform/programs/) - [Conferences](https://www.advancing-derm.org/platform/conferences/) - [Hacking Dermatology](https://www.advancing-derm.org/hacking-dermatology/) - [AID Accelerator](https://www.advancing-derm.org/platform/programs/aid-accelerator/) - [Previous Programs](https://advancing-derm.org/about/success-stories/) - [Virtual Magic Wand](https://www.advancing-derm.org/platform/aid-scholars/virtual-magic-wand-program/) - [Scholars Class 2019](https://www.advancing-derm.org/scholars-class-2019/) - [Scholars Class 2018](https://www.advancing-derm.org/scholars-class-2018/) - [Scholars Class 2017](https://www.advancing-derm.org/scholars-class-2017/) - [Media](https://blog.advancing-derm.org) - Events - [Contact](https://www.advancing-derm.org/contact/) [Twitter](https://twitter.com/AdvancingDerm)  |    [LinkedIn](https://www.linkedin.com/company/advancing-innovation-in-dermatology-inc-/) [![](https://blog.advancing-derm.org/hubfs/AID-logo.png)](https://www.advancing-derm.org) - [MEDIA](https://blog.advancing-derm.org) - [EVENTS](https://www.advancing-derm.org/events) - [CONTACT](https://www.advancing-derm.org/contact) Menu - [About](https://www.advancing-derm.org/about) - [About](https://www.advancing-derm.org/about) - [Vision / Mission](https://www.advancing-derm.org/about) - [Our Strategic Partners](https://www.advancing-derm.org/about/partners) - [Success Stories](https://advancing-derm.org/about/success-stories/) - [PEOPLE](https://www.advancing-derm.org/about/members) - [Executive Committee & Board of Trustees](https://www.advancing-derm.org/about/members/executive-committee-board-of-trustees) - [Conference & Program Leadership](https://www.advancing-derm.org/about/members/conference-and-program-leadership) - [Platform](https://www.advancing-derm.org/platform) - [Programs](https://www.advancing-derm.org/platform/programs) - [Leadership Councils](https://www.advancing-derm.org/platform/programs/leadership-councils/) - [Previous Programs](https://advancing-derm.org/about/success-stories/) - [Conferences](https://www.advancing-derm.org/platform/conferences/) - [Dermatology Innovation Forum 2026](https://advancing-derm.org/platform/conferences/dermatology-innovation-forum-2026//) - [Dermatology Summit](https://advancing-derm.org/dermatology-summit/) - [Media](https://blog.advancing-derm.org) - [Events](https://www.advancing-derm.org/events) - [Contact](https://www.advancing-derm.org/contact) # Innovation Spotlight: Diagnostics ### Now Viewing Articles [View Events](https://pages.advancing-derm.org/resources?hs_preview=lxMkcykJ-77280682771) Advancing Innovation in Dermatology is pleased to make available our collection of scholar articles, industry news, and interviews with the professionals accelerating innovation in skin health and patient care. This content is yet another way beyond our in-person and virtual events to strengthen the community of innovators we aim to build and maintain. Jun 17, 2021 By: Alexander Fogel MD, MBA ### Recent innovations point to a clinical future where diagnostics are less invasive and information is tailored to individual patients. #### Genetic scoring system to predict metastasis in cutaneous squamous cell carcinoma. Using a 40 gene expression profile on SCC biopsy specimens, the authors stratified patients with high-risk SCC into classes based on metastatic risk, and found a higher positive predictive value for the highest risk patient as compared to current scoring systems. Gene expression profiling tests have previously been available for cutaneous and uveal melanoma, breast cancer, prostate cancer, and this research is the basis for Castle Bioscience’s newly introduced DecisionDX-SCC genetic expression profiling test. ![](https://blog.advancing-derm.org/hs-fs/hubfs/Imported_Blog_Media/Screen-Shot-2021-06-17-at-10_03_07-AM-264x160.png?width=264&height=160&name=Screen-Shot-2021-06-17-at-10_03_07-AM-264x160.png) Wysong et al. “Validation of a 40-Gene Expression Profile Test to Predict Metastatic Risk in Localized High-Risk Cutaneous Squamous Cell Carcinoma.” J Am Acad Dermatol. 2021 Feb;84(2):361-369   Dr. Fogel asked lead author Dr. Ashley Wysong, Founding Chair and William W. Bruce MD Distinguished Chair of Dermatology, to put her work in context: *AF: How does this work improve the current state of clinical care or research?* AW: This work improves the current state of care in high-risk squamous cell carcinoma by integrating tumor biology into traditional clinicopathologic staging. Specifically, this validated gene expression profile test was able to differentiate tumors into three risk classes for metastasis which we believe are relevant for patient care. 40-GEP, used in conjunction with traditional staging, has the potential to significantly impact the treatment planning and prognosis of many of these high-risk SCC tumors. *AF: How do you envision this work entering the clinic in the future?* AW: I envision a dermatologist in the future using this approach to identify a subset of SCC patients that may benefit from additional management, such as adjuvant therapies, nodal staging, and increased surveillance while also preventing over treatment for tumors with a low risk of metastatic potential. - [Tweet](https://twitter.com/share) ### AID In the News ### Posts by Tag - [News (32)](https://blog.advancing-derm.org/tag/news) - [Articles (31)](https://blog.advancing-derm.org/tag/articles) - [Interviews (10)](https://blog.advancing-derm.org/tag/interviews) - [Entrepreneurship (9)](https://blog.advancing-derm.org/tag/entrepreneurship) - [Events (4)](https://blog.advancing-derm.org/tag/events) - [Innovation Review (3)](https://blog.advancing-derm.org/tag/innovation-review) - [Press Releases (3)](https://blog.advancing-derm.org/tag/press-releases) - [AID Accelerator (2)](https://blog.advancing-derm.org/tag/aid-accelerator) - [Awards (2)](https://blog.advancing-derm.org/tag/awards) - [Dermatology (2)](https://blog.advancing-derm.org/tag/dermatology) - [Business (1)](https://blog.advancing-derm.org/tag/business) - [biotech (1)](https://blog.advancing-derm.org/tag/biotech) See all ![AID-logo-white](https://blog.advancing-derm.org/hs-fs/hubfs/AID-logo-white.png?width=300&height=183&name=AID-logo-white.png "AID-logo-white") ##### Quick Links - [Media](https://blog.advancing-derm.org/) - [Upcoming Events](https://www.advancing-derm.org/events) - [People](https://www.advancing-derm.org/about/members/) ##### Connect with us If you would like to contact Advancing Innovation in Dermatology Inc., please [contact us](https://www.advancing-derm.org/contact). ##### Signup for updates Advancing Innovation in Dermatology Inc. is a nonprofit, tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code. Donations are tax-deductible as allowed by law. | [Privacy Policy](https://www.advancing-derm.org/privacy-policy/) | [Cookie Policy](https://advancing-derm.org/cookie-policy) © 2025 [Advancing Innovation in Dermatology Inc.](https://blog.advancing-derm.org/). All Rights Reserved. | Web Design & Development [**time4design**](https://www.time4design.com/) - [Bucks County Web Design](https://www.time4design.com/about). ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Alexander Fogel MD, MBA", "url" : "https://blog.advancing-derm.org/author/alexander-fogel" }, "dateModified" : "2022-11-10T21:38:50.369Z", "datePublished" : "2021-06-17T10:23:31.000Z", "headline" : "Innovation Spotlight: Diagnostics - Advancing Innovation in Dermatology", "image" : [ "https://blog.advancing-derm.org/hubfs/Imported_Blog_Media/AID_Innovation_Diagnostics_800x400.png" ], "mainEntityOfPage" : { "@id" : "https://blog.advancing-derm.org/articles/innovation-spotlight-diagnostics", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.advancing-derm.org/hubfs/Partners/Sponsor%20Logos%202023/AIDlogo_final_color.jpg" }, "name" : "Advancing Innovation Dermatology, Inc." } } ```